I have done some homework and been thinking there must be somebody out there who has done it!
After living in Mexico for some eight years I don't expect any problems down to the border of guatemala.
I will avoid driving at night, take the Pan-American Highway and a map, possibly a GPS, and hopefully find some company to avoid the single female troubles of travelling.
I speak fairly well spanish, but I am wondering about the rest of the trip and areas to visit in panama. Actually I am thinking about moving there since all I have read so far sounded just great to me.

Any input will be appreciated! Saludos, nikita