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Panama City to David is four-lane (two in each direction) and two-lane (one in each direction) -- it alternates. The road from David to Boquete is two-lane, and is easy and non-scary.
The wildest driving is in Panama City. When you head to the interior, you just have to be alert for crazed busses and big trucks that take too many chances. Also, in a rental car you can be a target for the police -- so, obey the speed limits (and it's sometimes hard to see the signs).
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